ISSN 1662-4009 (online)

ey0017.1-5 | Hypopituitarism: Disease Modeling and New Discoveries | ESPEYB17

1.5. Hypothalamic contribution to pituitary functions is recapitulated in vitro using 3D-cultured human iPS cells

T Kasai , H Suga , Sakakibara , C Ozone , R Matsumoto , M Kano , K Mitsumoto , K Ogawa , Y Kodani , H Nagasaki , N Inoshita , M Sugiyama , T Onoue , T Tsunekawa , Y Ito , H Takagi , D Hagiwara , S Iwama , M Goto , R Banno , R Takahashi , H Arima

To read the full abstract: Cell Rep. 2020 Jan 7;30(1):18–24.e5. doi: 10.1016/j.celrep.2019.12.009. PMID: 31914385.The hypothalamic-pituitary axis influences many body organ systems and its dysfunction can be fatal. A proper in vitro model is important for understanding the disease mechanisms affecting pituitary function. Based on their previous anterior pituitary modelli...